Please try this,

Load Apache::Registry, then include the handler, before the PerlHandler Apache::Registry bit. Suggest also that you do all the module loading/startup before specifying any handlers

eg . from my mod_perl.conf

        PerlRequire             conf/startup.pl
        PerlFreshRestart        on

        PerlSetVar StatusOptionsAll On
        PerlSetVar StatusTerse On
        PerlSetVar StatusTerseSize On
        PerlSetVar StatusTerseSizeMainSummary On

        Alias /perl-bin/ /usr/local/apache/mod_perl/

        PerlModule Apache::DProf
        PerlModule Apache::Registry
        PerlModule B::TerseSize
        PerlModule Apache::Status

        <Location /perl-bin>
                SetHandler perl-script
                PerlHandler Apache::Registry
                Options ExecCGI
                PerlSendHeader On
                allow from all
        </Location>
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