Probably the easiest way would be to set $/ = \16 so that you read the file in 16 bytes chunks.

Ie. $/ = \16; while( my $line = <INFILE> ) { willresult in $line containing 16 bytes each time, which will give you your 8 values per output line.

Simplistically, that make the program something like:

#! perl -lw
use strict;

## Note the -l above which makes print add newlines.

open IN, '<:raw:perlio', $ARGV[0] or die $!;
open OUT, '>', 'junk.out' or die $!;
$/ = \16; ## read 16 bytes at a time;

print join ',', map{ sprintf '0x%04x', $_ } unpack 'v*', $_ while <IN>
+;
close OUT;
close IN;
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If there was (still) some way to binmode *ARGV, it could be reduced to a one-liner:

perl -nle"BEGIN{$/=\16}print join',',map{sprintf'0x%04x',$_}unpack'v*'
+,$_" binfile >outfile
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but without binmode, that fails if the file contains a ^Z (control-Z; ascii 26) character.

Or you can go the other way and 'PBP-up' the above.