While you can sort of "unload" a package by undefining its symbol table hash (be sure to free up all objects of that package first, or they'll be hanging around in the __ANON__ package) and removing the package file entry from %INC, that won't gain you much, since perl won't give back memory to the OS. Then, for the next request, you would reload that package anyways?

If you are not using apache, you have to set up your listener by yourself, it is not provided by this module. You could go with Net::Server to implement it, if you don't want to go the Apache route. Be aware there's also FastCGI besides mod_perl.