I more suspect gcc-4.1.1. I currently build perl on HP-UX 11.23/pa with gcc-4.2.1 (when building with gcc).

The perl from which the -V is shown is a 32bit perl. I agree that -e should not fail, but it means that you cannot address the region beyond 2G unless you're reding it as a stream. Offsets to seek () and such still are 32bit only. I see more and more use for 64bit perls on 11i v2 all along the line. I only use 64bit perl on 11i v1 and up (still on 32bit perl on 10.20 and 11.00)

Do not build 64bit perl with gcc-4 on 11.11. Maybe 4.2.1 has the issues fixed by now, but otherwise you are heading for trouble.

The 64bit perl I have running on 11.23/pa does not have -D_FILE_OFFSET_BITS=64 defined, but I build with HP C-ANSI-C and -Ae