# 'LIBSSH2_APINO'
# doesn't match '(?-xism:^\d{12}$)'
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I'd suspect this has to do with LIBSSH2_APINO recently having been removed from the public header file of the underlying library libssh2. (If it's not there, it cannot match \d{12}.) In other words, your library might be too new (>= v0.16).

This could be a harmless problem (not sure though)... in any case, if no bug report has been filed already (I haven't checked), it's probably worth telling the author of Net::SSH2 about the modified header file...