Under NT I have had much more success using Win32::Gui, it runs faster then TK, and the look and feel are native to the Win32 OS.

Win32::GUI is a Win32-platform native graphical user interface toolkit for perl. basically, it's an XS implementation of most of the functions found in user32.dll and gdi32.dll, with an object oriented perl interface and an event-based dialog model that mimic the functionality of visual basic.