Better in what sense?

If the string may contain characters special to a regex that you want treated as regular characters to match, do /(\Q$string\E){3}/.

Make the match non-capturing, since you are unlikely to be using the captured result: /(?:\Q$string\E){3}/.

If the "3" is always the same and for some reason it isn't fast enough, try repeating it: /\Q$string$string$string\E/.

Save the regex in a variable and reuse it: my $regex = qr/\Q$string$string$string\E/; ... if ($line =~ $regex) ....