Yes. Take a look at DBIx::Simple, which is a layer over DBI. You really don't need a lot of code:

use DBIx::Simple;
$db = DBIx::Simple->connect(...);  # just as with DBI
$db->insert($table, \%hash);
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See SQL::Abstract for the syntax, which DBIx::Simple uses for its implementation.

Behind the curtains, it builds and prepares statements using placeholders, and it keeps a pool of cached statement holders, so repeated use of calls will be quite efficient: it'll try to avoid preparing the same statement over and over again.