No problems at all. As
randyk pointed out, it's just a matter of setting the path appropriately. For that I just run a batch script whenever I open a cmd.exe console. If I want to use Strawberry Perl I would run
strawberry.bat - if I want to run ActivePerl build 1001 then I run
ap1001.bat, or
ap822.bat for ActivePerl build 822, etc. I find that a lot easier than typing in the appropriate path amendment (which I usually can't remember anyway)
Cheers,
Rob