Supposing your MySQL user is GRANTed the CREATE privilege, and you connect as per chromatic's post above, you can then do something like:

my $sth=$dbh->prepare('CREATE DATABASE IF NOT EXISTS foo');
$sth->execute();
[download]

Your MySQL user does need to have had CREATE privileges GRANTed to them on a global level.

--
Me spell chucker work grate. Need grandma chicken.