my quick replay is: yes they are compatible BUT they does not work well together:
1-you have to use the minor-useful perl.dll
2-you get into a lot of blind error filled dungeon..
3-you have many account problem
4-if you wish to use some more complex then a primitive club it will be a pain to debug
Comment on Re^2: IIS & perl - are they compatible ?
I agree with all of your points, but unfortunately they don't apply just to perl. The blind dungeons and difficult to manage permissions issues are endemic to C# as well. In reality, it is the model imposed by IIS that causes most of these problems.
That wouldn't even be so bad if it weren't for the lack of accessible, correct documentation. The LAMP world has MS beat by a mile when it comes to quality support tools.