System-specific:

system(1, qq{"C:\\Program Files\\VideoLAN\\VLC\\vlc.exe" --rc-host 127
+.0.0.1:9999});
[download]

Note the leading 1,. Documented in perlport.

(I avoid the multiple arg form of system and exec on Windows for hardcoded commands since Windows doesn't have such a feature. Perl guesses at what the command should look like.)

Portable:

IPC::Open3