Thanks for your wide answer. I'll keep in mind some of your tips. Yes, I researched documentation of mod_rewrite and LocationMatch configuration directive may be useful for. But I founded in google impossible to invert the whole regex in this directive. Eg this code is impossible as I understood:

<LocationMatch <B>!~</B> /^(images|styles|js)/ >
    PerlOptions +Parent +GlobalRequest +Autoload
    PerlSwitches -I/some/path/lib

    SetHandler perl-script
    PerlResponseHandler My::Apache::Main
</Location>
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