Try this. It's a starting point.

#! perl -slw
use strict;
use threads;
use Win32::GUI;

my $mw =  Win32::GUI::Window->new(
    -name   => 'Main',
    -width  => 500,
    -height => 500,
);
my $lb = $mw->AddListbox( -name => 'LB' );

$lb->Add( 'Line ' . $_ ) for 1 .. 10;

$mw->Show();

my $thread = async{
    my $lb = shift;
    $SIG{'KILL'} = sub { return 0; };
    my $n = 11;
    while( sleep 1 ) {
        $lb->Add( 'Line ' .  $n++ );
    }
} $lb;
$thread->detach;

Win32::GUI::Dialog();

exit(0);

sub Main_Terminate {
    $thread->kill( 'KILL' );
    return -1;
}

sub Main_Resize {
    $lb->Width( $mw->Width );
    $lb->Height( $mw->Height );
}

sub LB_Click {
    print 'click';
}

sub LB_MouseRightDown {
    print 'Rclick';
}
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