1. If I install this, will it fcuk with my registry or otherwise screw with my current working copies of Perl?

Only your user-specifc %PATH% environment variable is changed, and that can be disabled during the install.

(I saw that modifying the path is optional) 2. Is everything install below c:\camelbox?

Yes, everything is installed below C:\camelbox. No, you can't modify the install path (yet).

3. Can I install this on a different drive?

No, not right now.