Per the Cookbook -

use Win32::Process;

Win32::Process::Create($Win32::Process::Create::ProcessObj,
    'c:/perl/bin/perl.exe', #path to perl
    'perl script.pl',       #perl script
    0,
    DETACHED_PROCESS,
    ".")or
    die "$!";
[download]

I have used this in the path with no issues - mainly for Tk apps.