The reason I said "first ignoring..." was that there may be a misconception by the Bioperl devs that splitting a distribution up into lots of little pieces may be frowned upon by the CPAN people. Therefore if this is not the case, then the decision becomes a trade off between ease of maintainance and ease of installation/re-usability for the end user.

Discussions are currently underway to split Bioperl into smaller chunks, and we need all the facts to help decide at what level it is best to split it.

Thanks for your quick feedback,
Nathan