it fails with a runtime error saying that the app tried to load the c++ runtime library incorrectly

Does it say which runtime library failed to load correctly ?
ActivePerl is built using MSVC++ 6.0 and, whilst you'll be able to build most modules for ActivePerl using MSVC++ 8.0 (or 7.x or 8.x or 9.x), there can be instances where the mixing of different runtime libraries won't work. In those instances you need to avoid mixing runtimes - and that can be achieved by using either MSVC++ 6.0 or MinGW compiler with ActivePerl.

Not sure if Win32::Clipboard is subject to this gotcha ... but I wouldn't be surprised if it is. In any case, the ppm to which marto directed you should be fine, as those binaries are built using MSVC++ 6.0.

Cheers,
Rob