Do you know exactly how many lines you want removed from the top and bottom of the file? If so, it can be as easy as

# read all the lines in the file into an array
@all_lines = (<INFILE>);
# grab only the lines you want
@stripped_lines = splice(@all_lines, 3, scalar(@all_lines)-5);
# output to the new file
print OUTFILE @stripped_lines;
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Otherwise, if you need to evaluate the data before knowing which lines to remove, you're looking at a regular expression.