You may take advantage of Vim's Quickfix List window.

Place this in your .vimrc:

    function! RunCmd(cmd)
      let fn = expand("%:p")
      let ft = &l:filetype
      botright copen
      setlocal modifiable
      %d _
      silent execute "read !".a:cmd." ".fn
      1d _
      normal! 0
      if ft != ""
        execute "setf ".ft
      else
        setlocal filetype=
      endif
      setlocal nomodifiable nomodified
      wincmd p
    endfunction

    command! -nargs=1 Run     call RunCmd(<q-args>)
    command!          RunPerl call RunCmd("/usr/bin/perl")
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Then, while editing your script in the current Vim buffer, do:

    :RunPerl
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or

    :Run perl
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You should be able to also map these commands to shortcut keys. YMMV -- perhaps something like:

    nnoremap <silent><F5> :<C-u>up|RunPerl<CR>
    inoremap <silent><F5> <C-o>:up|RunPerl<CR>
    vnoremap <silent><F5> <Esc>:up|RunPerl<CR>gv
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