By two byte chars I presume you mean they are from the unicode charset. Looking through the utf pages in the docs I get the impresion that your syntax may be a bit off. I had a play with the following code and had no problems deleting pairs of chars...

use utf8;
my $data = "\x{200}\x{201}\x{102}\x{200}\x{210}\x{375}\x{ab}\x{263A}";
#                  XXXXXXXXXXXXX        XXXXXXXXXXXXX
# Blocks marked with an x are deleted

print $data, "\n";

$data =~ s/
        (\x{201}[\x{101}-\x{114}]|
         \x{202}[\x{237}-\x{262}]|
         \x{203}[\x{100}-\x{177}]|
         \x{203}[\x{200}-\x{227}]|
         \x{210}[\x{237}-\x{375}])
    //gx;

print $data;
[download]

I hope this goes some way towards helping.

$japh->{'Caillte'} = $me;