Regexp::List (from the same distro) is the appropriate choice when the inputs are text strings (as opposed to regexp patterns).

use Regexp::List qw( );
my $re = Regexp::List->new()->list2re( 250..730 );
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In Perl 5.10, the regexp engine already does that for you.

use 5.010; # Trie alternations
my ($re) = map qr/$_/,
           join '|',
          #map quotemeta,  # Not needed this time.
           250..730;
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