I have been working with this recently, so I'm very glad to share my experiences. For what they are worth.

Personally, I had some frustration getting Tk working with IndigoPerl, but no problems whatsoever with ActiveState. Win32 worked fine with either. (Though IMHO it's more likely it was my fault than anything else, to be sure.)

As far as working with them... I can only add to the voices here in expressing a distinct preference for Tk. Since neither is supported on Macintosh, there is no real cross-platform GUI support anyway. However, you can at least have the opportunity to share your work with the rest of the community & help Save The World by writing PERL code. :-}

Plus, if you look at the Big Picture you'd realize that a Tk module for the Mac platform would be forthcoming a lot faster than say a Win32 module. :-\

Though, you did say that compatability wasn't an issue, I simply suggest it's something that you look at from both sides. With a greater audience comes a greater amount of shared code resources. You'll find more examples & help in the long run using Tk because of compatability.

Also, as noted previously, it doesn't crash as much! 8-P