Perl and lots of other more dynamic languages are not really a good match for a "traditional" IDE like Eclipse: you can use them, but those IDEs don't really add much over plain editors.

A system that interacts with a running "image" (program) has more potential, like Emacs/Slime for lisp, or some of the small-talk environments show, though I haven't really found one that's as polishes as Slime. Sepia seems like a step in the right direction, though.