The Anonymous Monk has already mentioned pVoice which is the classic example of GUI written in Perl (wxWidgets in this case) and with a lot of love, caters to some kind of disability.

It is probably not the same accessibility issue you are facing but to ignorants like me they seem to be related.

I have been using wxPerl for some time now to build Padre an IDE for Perl. As a off-shot from that project I started to create a library to make it easy to add GUI to existing command line scripts.

Writing a real GUI application is very different from a command line application as the former is event driven. The module I wanted to create would help overcome the difficulty for the simple cases. It is in very early stages and I have not addressed any accessibility issues but I'd be glad if you checked out Wx::Perl::Dialog::Simple in Wx::Perl::Dialog and helped me in turning it into something that is really useful for such applications.

To address the four issues you raised

• Fully keyboard-navigable - this is up to the developer I think, You can do it with wxPerl
• The ability to work with assistive/adaptive technologies. - This is the area where I have no experience at all, but I'd love to get feedback on this.
• Tooltips are available.
• Cross-platform operation: Windows and Linux work quite well (after some installation troubles). I think OSX too, but I heard slightly more trouble there.