I think that what I would conclude from what you are saying is that GTK2 is probably worth consideration if we control the environment in which our software can be run. (Such as if we could specify Linux/Gnome or Solaris/Gnome.)

In the case of businesses and institutions, this could well be the case - and we could also save a fortune on AT software licenses using Open Source ATs on an Open Source platform. I know for a fact that the JAWS screen reader is not cheap.

Otherwise, however, when looking at deploying Perl/GUI applications cross-platform, Wx/Perl is looking to be the better candidate. Thanks for your input into this.