In mod_perl 2, the PerlHandler directive has been renamed PerlResponseHandler. PerlResponseHandler is a RUN_FIRST type and this means processing will stop when an OK is returned. To get multiple handlers to run, you need to return DECLINED or pick a different phase where all handlers run (type RUN_ALL). The solution depends on what you are doing in your handlers. The mod_perl 2 stacked handler docs might help.