use strict;
use warnings;
use Sockets;

    $wishbin = 'C:\Progra~1\TclScripts\bin\wish84.exe C:\Progra~1\bin\
+WishSetup.tcl';

    die "socketpair unsuccessful: $!!\n" unless socketpair(W0,WISH84,1
+,1,0);
    if ($pid=fork) {
    print "PID: $pid\n";
    select(WISH84); $| = 1;
    select(STDOUT);

    print WISH84 'source TCL_Script.tcl',"\n";

    # Here is the main loop which receives and sends commands
    # to wish.
    while (<WISH84>) {
        chop;
        print "Wish sais: <$_>\n";
        if (/^quit/) { print WISH84 "destroy .\n"; last; }
    }
        wait;
    } elsif (defined $pid) {
    open(STDOUT, ">&W0");
    open(STDIN, ">&W0");
    close(W0);
    select(STDOUT); $| = 1;
    exec "$wishbin --";
    } else {
    die "fork error: $!\n";
    }
[download]

fork/exec would be a good model to follow on *NIX, but on Windows fork creates a new thread, not a new process.

I guess TCL is incompatible with Perl, but, depending on the complexity, it might be easy to read the TCL and figure out environment settings in Perl before launching the main TCL script as a child process (using system).
Or you could rewrite the setup script to use Perl then call it using do.
Failing that, why can't the main TCL script read the TCL environment file setup?