There is a project called Guido which aims to be exactly what you describe. However it hasn't been updated in several years, so I don't know what state it's in.

Personally If I needed to do a Perl GUI, I would go for something QT or GTK+ based as both are cross platform and have perl bindings and fairly mature GUI building tools in QTDesigner and Glade. Both tend to look more "modern" and polished than TK in my opinion.