At YAPC::NA 2008, I attended a talk by Timothy Appnel where he discussed Amazon's cloud computing and the Perl support for it. That was last summer.

My recollection is that there's support for the various Amazon offerings, but they all have their own interfaces, and they overlap in a few areas. What's needed is a unified module with a consistent interface for everything. Amazon-Bezos was supposed to be that, but I see it hasn't changed since summer, and it's still labeled a prototype. Still, it might be a good place to start looking.

I recall the author saying that he could use some help with the project. If you have some spare time, you could make a name for yourself bringing the might of Amazon to Perl.