No and yes.

No, in that Perl runs strictly server-side, not in the user's web browser. Doing what you want will require javascript code which will run in the browser.

Yes, in that, by using CGI::Ajax, you can do it without writing any non-Perl code yourself. CGI::Ajax allows you to write server-side Perl subs which are intended to be called by client-side javascript and then deals with the javascript glue required to make this happen for you.