Sure. Try it out, and measure the difference.

You can also try to measure the startup and initialization phase, and see if it's large enough to warrant the effort.

#!/usr/bin/perl
use Time::HiRes qw(time);
my $start; BEGIN { $start = time() };

# rest of module loading here
# then initialization (open database connections etc.)
warn "Startup time: ", time() - $start; 

# rest of script goes here
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