I wrote bindings for OGRE. I found them to be fairly fast, actually, though of course most of the execution is done in C++ land.

You probably don't mean Perl specifically, but interpreted languages generally. But from what I see, a lot of times there are no bindings for Perl when there are for Python and Ruby. I think the reason for not writing bindings is not the speed (Perl is probably faster than Ruby, I don't know about Python) but rather the ease of writing the bindings. For example, for Python there is Py++; we don't have the equivalent of that for Perl.