I've seen Perl presentations in Powerpoint, Open office, PDF, Magicpoint, plain HTML, javascript generated HTML, LaTeX, and even vi(m) (by well known Perl authors like Damian and Ingy).

Most of the presentation forms had more than one method of generating - and a lot of people use their own something-to-something-else translators.

I'd think that if there was a "best software" for giving presentations, people would converge on that. I do not so such a trend. Different people, different presentations, different preferences. Not to mention people change preferences over time.

I'd say, use whatever you find comfortable. I keep using my own text-to-HTML compilers.