You can use DBD::ODBC, which is a database driver for DBI:

my $dbh = DBI->connect('dbi:ODBC:DSN', 'user', 'password');
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And, I presume, you just use $dbh just as you would for any other database driver.

Or you could use Win32::ODBC:

my $Data = new Win32::ODBC("MyDSN");
$Data->Sql(SQL);
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