If you are on Win32 box, i'd suggest use of "Win32::OLE"
To get you started, here's a small piece of code:

use Win32::OLE;
$Excel = Win32::OLE->GetActiveObject('Excel.Application') || Win32::OL
+E->new('Excel.Application');
$Excel->{'Visible'} = 1; #to make it visible
#my $Book = $Excel->Workbooks->Open('E:/perl scripts/abc.xls') || die 
+"could not open excel file"; # open Excel file
 
$Excel->{SheetsInNewWorkBook} = 1; 
$workbook = $Excel->Workbooks->Add(); 
$Sheet = $workbook->Worksheets(1); 
$Sheet->{Name} = "New WorkSheet"; 
$Sheet->Range("A1")->{Value}="My cell number 1";
$workbook->SaveAs({Filename =>'abc.xls',  FileFormat => xlWorkbookNorm
+al});
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