How are you going to processes it? Ie. Can you process it in smaller chunks than the whole file? If so, read it in smaller chunks using read (or by setting (say) $/ = \4192;).
Examine what is said, not who speaks -- Silence betokens consent -- Love the truth but pardon error.
"Science is about questioning the status quo. Questioning authority".
In the absence of evidence, opinion is indistinguishable from prejudice.