Not as such that comes to mind, but you might look into PersistentPerl, which transparently handles keeping the backend perl process going while subsequent invocations talk to that existing instance (think FastCGI, but not tied to a CGI / web server request context).

Another alternative would be to use something like SOAP::Lite or another RPC mechanism and have a persistent backend server which answers requests from thin clients which just marshal requests into SOAP calls and return the result.