I only check the original intended target: manual pages. If it looks good in 'pod2man Foo.pm | nroff -man | less' on a 80 character window, I'm ready to ship it.
Yes, but pod2html won't catch issues where pod2man generates code that cannot be dealt with *roff correctly. Furthermore, I don't want any generated lines to be over 80 characters wide (which can easily happen with (non-formatted) code). Easy to check with pod2man - much harder to check to with pod2html.
Plus I don't need a browser that way; I can just do it all from the command line (which is important for me, as $WORK means I code remotely).