One way:

#!C:/Perl/bin
use warnings;
use strict;
# #801473

my $temp = 'F:\fake.htm';

chdir ('C:/Program Files/rest/of/path');    # to program.exe

system("program.exe $temp");
[download]

This will work, of course, only for programs that actually run in the cmd window; if you want to run a W32 program, you'll want to revise your SOPW.

Update:

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