...i recommend using Gtk2....why? ..... the basic c libs now come standard on linux, so as to run firefox and gimp and such..... there is also very active and widespread development within gtk2.....

there is a tutorial at Perl Gtk2 tutorial and to get a Perl version easily installed on win32, that comes with all the Gtk2 stuff installed, try Camelbox: A build of Gtk2-Perl for Windows

...another benefit of perl-gtk2 is that it clearly parallels the c libs in names and stuff, so you can port your app to c later, and there are many gtk2-c tutorials available and very good mailling lists for both c and perl..... be warned however, before asking questions on the maillist, they expect you to at least have gone thru the tutorials, and show some code.

...the drawback to gtk2 ( actually an advantage in my books) compared to Wx, is that there is no easy to use GUI designer, .... no gui layout manager, forces you to make your own windows, do the packing, and signal setup yourself....this is important if you want to write more advanced stuff

....alot of people like Wx, which has a more c++ style, where as gtk2 is more like plain c, with a bunch of extra data types thrown in.... into a basic event loop and object system called Glib.....just read up on it...its all free