I cannot imagine what you are talking about here.

What kind of operations you'll be doing with these numbers that could take too much to get completed ?

Are those data preloaded into a database? or you'll be parsing some text files over and over to do the calculations?

Have you considered relying on the database engine (if you use one) to do the basic calculations to make things faster/smoother.

If you're going to make it in Perl then I'd like to get updated on this (Might give us an estimation on how far we could go with our Perl based solutions :P ).