I'm far from an expert in Catalyst (only started trying to use it within the past week myself) but I would guess that it depends on what type of site you're looking at developing. Is Catalyst right for you? It'd probably be overkill for a very small site, but if you want a good framework, I've heard Catalyst is very good at the MVC architecture. It probably also depends on time, and whether or not you know how to use it, or how long it would take to learn it. Based on the number of dependency modules I had to install for Catalyst, I'm guessing it can be pretty complex.

Hopefully one of the more Catalyst-experienced monks will chime in.