Assuming you want to match "words", and not part of words (that is, if one of your keywords is "perl", you don't want it to trigger on "properly"), I'd do the following (untested):

use 5.010;
use strict;
use warnings;
use autodie;

open my $kwh, "keywords.txt";
while (<$kwh>) {
    chomp;
    $keyword{$_}++ for split /,/;
}
close $kwh;
open my $fh, "Skypelogs.txt";
while (<$fh>) {
    print if grep {$keywords{$_}} /(\pL(?:\S*\pL)?)/g;
}
close $fh;
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Note the definition of a "word": any sequence of non-space characters that start and end with a letter. This is far from perfect.