First "I have downloaded Wx::Perl::Packager" sounds a bit fishy. Both Wx and Wx::Perl::Packager are available in the main Active State repository. You should use ppm to install Active State packages - just "downloading" won't get the job done. Just type "ppm" on a command line and a GUI window will start - use that to install packages.

I haven't used Wx before. I am not sure that you need this extra Packager if you are going to build a standalone .exe file. The current version of PerlApp is pretty smart about finding dependencies and getting them into the .exe. They have written some extra code with some heuristics for some of the major libraries, like Tk and hopefully Wx also.

What happened when you tried to make a standalone .exe without this extra packager?

Of course please confirm that you have an application that is working just fine with Wx before you tried to add this extra package manager?

Update: Making a .exe file with a graphical UI is definitely not a "simple.pl" job! This can get pretty hairy! PerlApp has gotten a heck of a lot smarter since the first time that I used it. But this can still be a "non-trivial" exercise. Are you able to make a .exe from some non-graphical UI program with PerlApp? It just seems to me that you are trying to make a very big leap in one step.