No problems if it is built correctly. See Camelbox: A build of Gtk2-Perl for Windows for an easy to install Gtk2 enabled Perl on Win32.... the only drawback is it dosn't come with a pre-built Tk module.... so you get Gtk2 but give up Tk, unless you can figure out the complicated compiler situation on Win32, so you can build Tk from the CamelBox Perl version. But CamelBox does come with all the Network and DBI modules.