Testing each value of a list sounds like a job for grep. When I need to determine if any elements of a list are true, I will usually use something that looks like:

if( grep $_, @opts{qw|a b c|})
{

}
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A cleaner version of this would be

if( grep $opts{$_}, qw|a b c|)
{

}
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You can use a couple negations to check if all values are true:

if( !grep !$opts{$_}, qw|a b c|)
{

}
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Note that your second suggestion will always return true, since you will always have a 3-element array in scalar context.