Do you get the segfault also for a "dummy script", such as

$ sudo perl -d:DProf -e1
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If so, maybe an incompatible DProf.so is being loaded (for example due to some inappropriate PERL5LIB setting, or some such).  You can check with

$ sudo strace -eopen perl -d:DProf -e1
...
open("/usr/local/perl/5.12.2/lib/5.12.2/x86_64-linux-thread-multi/Deve
+l/DProf.pm", O_RDONLY) = 4
open("/usr/local/perl/5.12.2/lib/5.12.2/XSLoader.pm", O_RDONLY) = 5
open("/usr/local/perl/5.12.2/lib/5.12.2/x86_64-linux-thread-multi/auto
+/Devel/DProf/DProf.so", O_RDONLY) = 4
open("tmon.out", O_WRONLY|O_CREAT|O_TRUNC, 0666) = 4
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The path the module is being loaded from should match the version of the perl binary you're using (what 'sudo which perl' says).