Unless you have an explicit need to use SOAP, don't. It's complex, weird, buggy, poorly specified, and prone to strange and incomplete implementations. (SOAP::Lite is usually pretty good, but you can only do so much with SOAP.)

If you do need web service capabilities, shipping around data in JSON format tends to work much better.

Any of the modern Perl 5 web frameworks is worth your time learning. Be sure to take advantage of Plack/PSGI compatibility, but Mojolicious or Dancer or Catalyst should do you well. Mojolicious in particular seems to focus on HTML 5 features, but any of the others will work too.