The -Duselargefiles option is supposed to be given to the Configure program when compiling perl. (Alternately you could answer all the prompts it gives if you don't give the options to turn those off.) According to the documentation given with perl's source kit, "in many common platforms like Linux or Solaris this support is on by default". You can test if your perl is compiled with large file support with perl -V:uselargefiles (should say uselargefiles='define'; if they are enabled.)

If large files are supposedly enabled you probably have a less easily solved problem. If they aren't you will need to (try to) recompile perl with large file support turned on.

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perl -e '$|--;$.=q$.$;while($i!=0){$i=(time-$^T)%60;print"\r".$.x$i}'